Chiralpedia

Blog

#TheAtropisomericAxis

• Atropisomerism in Action: The Sotorasib Story

#Chiral HPLC Series

• Episode 1: Why Chirality Still Matters: Stereochemistry as a Critical Quality Attribute
• Episode 2: Developing a Chiral HPLC Method: A Structure-Led Workflow
• Episode 3: State of the Art: Selectors, SFC, Speed, and Sensible Automation
• Episode 4: From Peak to Standard: Preparative Isolation of Chiral Impurities
• Episode 5: Defending the Method: Regulatory Expectations and Where the Field Is Heading

#Chiral Agrochemicals

• Episode 1: Introduction to Chirality in Agrochemicals
• Episode 2: Stereoselectivity and Biological Activity in Pesticides
• Episode 3: Herbicides and the Role of Chirality
• Episode 4: Fungicides and Stereochemistry
• Episode 5: Natural Products as Chiral Templates
• Episode 6: Environmental Impact of Chiral Agrochemicals
• Episode 7: Toxicity and Food Safety Considerations of Chiral Agrochemicals
• Episode 8: Sustainable Pest Management and Chirality
• Episode 9: Regulatory and Industrial Perspectives on Chiral Agrochemicals
• Episode 10: Future Directions in Chiral Agrochemistry

#Germanium

• Geranium: Beyond Carbon — A Chiralpedia Guide to a New Dimension of Chirality

#Chirality Descriptor

• X-ray Reveals the Truth. R/S Makes It Speak

#Stereogenic Sulfur

• Case Study Through the Chiralpedia Lens: tert-Butanesulfinamide — The Sulfur-Centered Chiral Tool That Changed Drug Synthesis

#Mirror Cells

• Mirror Life: When Chirality Flips, Does Biology Unravel?

#The Chiral Shift

• Why the Language of Chirality Must Evolve: When Molecules Speak in 3D and Models Listen in 2D
• Teaching Machines to See in 3D: The Chiral Blind Spot in AI-Driven Drug Discovery

#Chiral Bias in AI Drug Discovery

• Episode 1: The Promise and the Paradox: AI That Miss the Mirror
• Episode 2: Why Chirality Confuses Machines?
• Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline?
• Episode 4: Fixing the Bias: Data, Models and Generative Constraints
• Episode 5: Beyond Bias: Toward Chiral Intelligence

#Chiral Drug Engineering

• Chiral Drug Engineering: Building Safer, Smarter, and More Selective Medicines

#The Molecular Grammar of Medicines

• The Molecular Grammar of Medicines: Isomerism, Chirality, and Stereochemical Relationships Explained

#Hidden Chirality Series

• When Drug Labels Miss the Twist: The regulatory bind spot
• The Hidden Chirality in Drug Metabolites: A metabolic blind spot
• Teaching Machines to See in 3D: The Chiral Blind Spot in AI-Driven Drug Discovery

#Stereochemistry in Pharmaceutical Sciences: A Learning Series

• Part 1: Introduction to Stereochemistry
• Part 2: Fundamental Concepts of Chirality
• Part 3: Nomenclature and Configuration
• Part 4: Stereochemistry in Drug Action and Pharmacology
• Part 5: Stereoselective and Stereospecific Synthesis
• Part 6: Resolution of Enantiomers
• Part 7: Analytical Techniques for Stereochemistry
• Part 8: Stereochemistry in Biologics and Natural Products
• Part 9: Stereochemistry in Drug Discovery and Development
• Part 10: Stereochemistry in Pharmaceutical Sciences – Current Trends and Future Directions

#Mapping Stereochemical Nomenclature

• Mapping Stereochemical Nomenclature: A Chiralpedia Guide

#The Thalidomide Paradox

• The Thalidomide Paradox

#Racemates

• Racemates Less Safe. Rethink Chirality!

#The Regulatory Journey of Chiral Drugs

• Episode 1: When Mirror Images Mattered: A Historical Prelude to Chiral Drug Regulation
• Episode 2: The Great Shift: How the 1990s Redefined Stereochemical Standards
• Episode 3: Beyond Borders: Comparing How Global Agencies Regulate Chiral Drugs
• Episode 4: Technology as Catalyst: How Science Enabled the Regulatory Transformation
• Episode 5: Choosing the Right Twin: Regulatory Expectations for Single Enantiomers
• Episode 6: The Rise of the Chiral Switch: Strategy or Science?
• Episode 7: Clinical Questions: Are Single Enantiomers Always Better?
• Episode 8: Beyond the Approval: Ethical and Economic Dimensions of Chiral Drugs
• Episode 9: Challenges on the Horizon: Complex Chirality and Emerging Scientific Questions
• Episode 10: Future Reflections: How the Story of Chiral Drug Regulation Continues

#Chiral_Analysis

• Chiral_Analysis: Mapping the Essentials

#Chiral_Pharmacology

• Chiral_Pharmacology : The Mirror Image of Drug Development

#Chirality_From_OriginsToApplications

• P1. The Origin of Chirality: From Light to Life
• P2. The Building Blocks of Stereochemistry
• P3. Chirality in Medicine: From Discovery to Disaster
• P4. Catalysts of Change: Advancements in Asymmetric Synthesis
• P5. The Future of Chirality: Challenges and Innovations

#Chiral_Resolution

• The Fundamentals of Chiral Resolution: Why Chirality Matters
• Breaking Down the Methods: Chromatography and Crystallization in Chiral Resolution
• Innovations in Membrane and Kinetic Resolution for Chiral Separation
• Unconventional Approaches in Chiral Resolution: New Horizons
• The Future of Chiral Resolution: Green Chemistry and Sustainable Practices

#chiral_bioequivalence

• chiral_bioequivalence : Chiral Bioequivalence – An Explainer

#chiral_switch

• chiral_switch : Unlocking the Potential of Single Enantiomers

#chiral_drugs

• chiral_drugs : A twisted tale in pharmaceuticals

#Asymmetric_Synthesis

• Understanding the Fundamentals of Asymmetric Synthesis
• Recent Advances in Catalytic Asymmetric Synthesis
• Harnessing Computational Methods in Asymmetric Synthesis
• Asymmetric Synthesis in Industry: From Lab to Market
• The Future of Asymmetric Synthesis: Trends and Innovations

#ChiralityOnFriday

• Introduction to Chirality: Understanding the Basics
• Molecular Handedness: How Chirality Shapes Molecules
• Chirality in Nature: From DNA to Snail Shells
• The Chemistry of Taste and Smell: How Chirality Affects Senses
• Chiral Chemistry in Everyday Life: Hidden Handedness Around Us
• Chirality in Pharmaceuticals: The Impact of Molecular Handedness on Medicine
• Chirality in Materials Science: Designing with Handedness
• Chirality in Space: Cosmic Asymmetry and the Origins of Life
• The Future of Chirality: Innovations and Emerging Trends
• Chirality and You: Understanding and Appreciating Molecular Handedness

#hplc_method_development

• HPLC Method Development – prelude
• Selecting the tools
• Measuring quality of chromatogram – Tools 1.0
• Measuring quality of chromatogram- Tools 2.0
• Measuring quality of chromatogram- Tools 3.0
• Controlling selectivity-Solvent role-1.0
• Controlling selectivity-Solvent role-2.0
• Controlling selectivity-Additional factors-1.0 - pH
• Controlling selectivity-Additional factors-2.0 - temperature

#chiral_chromatography

• Chiral chromatography
• Chiral HPLC separation: strategy and approaches
• Direct chiral HPLC separation on CSPs
• Chiral selectors
• Polysaccharide-based CSPs
• Cyclodextrin-based CSPs
• Donor-Acceptor (Pirkle)-type CSPs
• Protein-based CSPs
• Separating mirrored molecules

#drug_withdrawls

• Thalidomide
• Dilevalol
• Terodiline
• Prenylamine

#cMOTW

• Morphine
• Quinine
• Ascorbic acid
• Levofloxacin
• Ethambutol
• Esomeprazole
• Salbutamol
• Dexibuprofen
• Propoxyphene
• Levobupivacaine
• Escitalopram
• Levocetirizine
• Indacrinone
• L-Dopa
• Beta-Blockers
• Levamisole
• Ibuprofen
• Terodiline

#naming_system

• Naming enantiomers: the left-(or right-) handed?
• Fischer Projection: hassle free way to depict a stereoformula in 2D projection
• Cis-trans and E-Z notation: choose your side
• The meso compounds: finding plane of symmetry
• Erythro- and Threo- prefixes: the (same-) or (opposite-) side?
• Atropisomers: things are tight, single bond won't rotate
• D-/L- system naming: the (left-) or (right-) hand side?
• Thalidomide tragedy: the story and lessons …
• Chiral twins – Identical? … But not really!
• The handed world …