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<#Asymmetric_Synthesis> - Asymmetric Synthesis in Industry: From Lab to Market
<#Asymmetric_Synthesis> - Harnessing Computational Methods in Asymmetric Synthesis
<#Asymmetric_Synthesis> - Recent Advances in Catalytic Asymmetric Synthesis
<#Asymmetric_Synthesis> - Understanding the Fundamentals of Asymmetric Synthesis

Asymmetric Synthesis

Asymmetric synthesis, also known as enantioselective synthesis, chiral synthesis, is a method used to preferentially produce one enantiomer over another. This technique is essential for creating chiral compounds that are used in a wide range of industries, from medicine to materials science. The ability to control the stereochemistry of molecules is crucial for the development of effective and safe pharmaceutical drugs, as well as for the creation of novel materials with unique properties...

The Nobel Prize in Chemistry 2021

Awarded Benjamin List and David MacMillan "for the development of asymmetric organocatalysis".

https://www.nobelprize.org/prizes/chemistry/2021/press-release/

The Nobel Prize in Chemistry 2018

Awarded one half to Frances H. Arnold "for the directed evolution of enzymes".

https://www.nobelprize.org/prizes/chemistry/2018/arnold/facts/

The Nobel Prize in Chemistry 2001

Awarded jointly to William S. Knowles and Ryoji Noyori "for their work on chirally catalysed hydrogenation reactions" and to K. Barry Sharpless "for his work on chirally catalysed oxidation reactions"

https://www.nobelprize.org/prizes/chemistry/2001/summary/

Learn

Useful Links

Understanding the Fundamentals of Asymmetric Synthesis

https://chiralpedia.com/blog/understanding-the-fundamentals-of-asymmetric-synthesis/

Recent Advances in Catalytic Asymmetric Synthesis

https://chiralpedia.com/blog/recent-advances-in-catalytic-asymmetric-synthesis/

Harnessing Computational Methods in Asymmetric Synthesis

https://chiralpedia.com/blog/harnessing-computational-methods-in-asymmetric-synthesis/

Asymmetric Synthesis in Industry: From Lab to Market

https://chiralpedia.com/blog/asymmetric-synthesis-in-industry-from-lab-to-market/

The Future of Asymmetric Synthesis: Trends and Innovations

https://chiralpedia.com/blog/the-future-asymmetric-synthesis-trends-and-innovations/

Read more @ the following articles.

Basics

Günter Helmchen, Definition of the term asymmetric synthesis - History and revision, Chirality, 2023

https://doi.org/10.1002/chir.23536

Key Concepts in Stereoselective Synthesis

https://ethz.ch/content/dam/ethz/special-interest/chab/organic-chemistry/bode-group-dam/documents/open-source-lecture-notes/key-concepts-in-stereoselective-synthesis-2015.pdf

Approaches

Transition Metal catalysis

Applications of Transition-metal-catalyzed Asymmetric Allylic Substitution in Total Synthesis of Natural Products: An Update.

Mohammadkhani, L., & Heravi, M. M.
The Chemical Record. 2020; doi:10.1002/tcr.202000086

Toward efficient asymmetric hydrogenation: Architectural and functional engineering of chiral molecular catalysts.

Ryoji Noyori, Masato Kitamura, and Takeshi Ohkuma
PNAS, 2004,101 (15) 5356-5362.
www.pnas.org/cgi/doi/10.1073/pnas.0307928100

Biocatalysis

Chirality Related to Biocatalysis and Enzymes in Organic Synthesis (343-406)

Chirality in Supramolecular Assemblies: Causes and Consequences
https://doi.org/10.1002/9781118867334.ch12

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014-2019).

de María, P.D.; de Gonzalo, G.; Alcántara, A.R.
Catalysts 2019, 9, 802. https://doi.org/10.3390/catal9100802.

Biocatalysis

Bell, E.L., Finnigan, W., France, S.P. et al.
Nature Reviews Methods Primers 1, 46 (2021). https://doi.org/10.1038/s43586-021-00044-z

State-of-the-Art Biocatalysis.

Pyser, J. B., Chakrabarty, S., Romero, E. O., & Narayan, A. R. H.
ACS Central Science,2021, 7, 1105-1116 doi:10.1021/acscentsci.1c00273.

Organocatalysis

How organocatalysis won the Nobel prize

By Jamie Durrani | 15 October 2021

A Noble Quest for Simplicity in the Chiral World

Svetlana B. Tsogoeva,
N Engl J Med., 2021, 385:2579-2581 DOI: 10.1056/NEJMcibr2116228.

Organocatalysis: Trends of Drug Synthesis in Medicinal Chemistry

Biswa Mohan Sahoo and Bimal Krishna Banik
Current Organocatalysis, 2019, 6, 92-105 doi: 10.2174/2213337206666

Asymmetric organocatalysis at the service of medicinal chemistry

Ricci A
ISRN Org Chem. 2014. doi: 10.1155/2014/531695. PMID: 24971178.

The advent and development of organocatalysis

MacMillan, D.W.C.
Nature, 2008, 455, 304-308.

Application

Asymmetric Synthesis of US-FDA Approved Drugs over Five Years (2016-2020): A Recapitulation of Chirality

https://pubmed.ncbi.nlm.nih.gov/36986439/

Rekha Tamatam, Dongyun Shin | 2023 Feb 22;16(3):339. doi: 10.3390/ph16030339.

Asymmetric Synthesis and Applications of Chiral Organoselenium Compounds: A Review

https://www.mdpi.com/1420-3049/29/15/3685

Yanyu Jian, Thishana Singh, Pher G. Andersson & Taigang Zhou | Molecules 2024, 29(15), 3685; https://doi.org/10.3390/molecules29153685.
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