Chiralpedia

Pharmaceuticals

Drug Chirality

"Many medicinal agents important to life are combinations of mirror-image twins. Despite the close resemblance of such twins, the differences in their biological properties can be profound. In other words the component enantiomers of a racemic chiral drug may differ wildly in their pharmacokinetic, pharmacodynamic profile. The tragedy of thalidomide illustrates the potential for extreme consequences"...

Read more @ the following articles.
"Chiral drugs" Wikipedia, Wikimedia Foundation

https://en.wikipedia.org/wiki/Chiral_drugs

"Chiral switch" Wikipedia, Wikimedia Foundation

https://en.m.wikipedia.org/wiki/Chiral_switch

Chiral drugs: Sources, absolute configuration identification, pharmacological applications, and future research trends

https://www.sciencedirect.com/science/article/pii/S3050474024000089
Links to some more publications in the area of drug chirality are given below. These articles and references therein might be of interest to readers.
"Chiral drugs" Wikipedia, Wikimedia Foundation

https://en.wikipedia.org/wiki/Chiral_drugs

Drug Chirality in Anesthesia

Richard B. Weiskopf, Carla Nau, Gary R. Strichartz
Anesthesiology, 2002, Vol. 97, 497-502.
https://doi.org/10.1097/00000542-200208000-00029

https://pubs.asahq.org/anesthesiology/article/97/2/497/40134/Drug-Chirality-in-Anesthesia

Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods

Maria Miguel Coelho, Carla Fernandes, and Fernando Remiao
Molecules 2021, 26(11), 3113.
https://doi.org/10.3390/molecules26113113

https://www.mdpi.com/1420-3049/26/11/3113/htm
Chiral pharmaceuticals: Environment sources, potential human health impacts, remediation technologies and future perspective

Yaoyu Zhou, Shikang Wu, Hao Zhou, Hongli, Huang Jia Zhao, Yaocheng Deng,, Hua Wang, Yuan Yang, Jian Yang, Lin Luo
Environment International, 121, 2018, 523-537.
https://doi.org/10.1016/j.envint.2018.09.041

https://www.sciencedirect.com/science/article/pii/S0160412018313709
Chiral Toxicology: It's the Same Thing...Only Different

Silas W. Smith
Toxicological Sciences, 110, 2009, 4-30.
https://doi.org/10.1093/toxsci/kfp097

https://academic.oup.com/toxsci/article/110/1/4/1668162
Association of Physicians of India: Position Statement on Role of Chirally Pure Molecules in Clinical Practice

Milind Y Nadkar et. al.
Journal of the Association of Physicians of India, 2017, 65 (12), 49-60.

https://www.japi.org/q26484c4/association-of-physicians-of-india-position-statement-on-role-of-chirally-pure-molecules-in-clinical-practice

Importance of chirality in drug therapy and pharmacy

Davies NM and Teng XW
Advances in Pharmacy 2003, 1(3):242-252.

https://www.researchgate.net/publication/281423185_Importance_of_chirality_in_drug_therapy_and_pharmacy_practice_Implications_for_psychiatry

A Look at the Importance of Chirality in Drug Activity: Some Significative Examples

Jessica Ceramella, Domenico Iacopetta, Angelica Franchini, Michele De Luca, Carmela Saturnino, Inmaculada Andreu, Maria Stefania Sinicropi, Alessia Catalano | Published: 27 October 2022

https://www.mdpi.com/2076-3417/12/21/10909

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