Improve your understanding of molecular properties with this lesson on the fascinating property of chirality. Your hands are the secret to understanding the strange similarity between two molecules that look almost exactly alike, but are not perfect mirror images.
Lydia Flynn describes the importance of chirality, the concept of "handedness", where the reflection of an object is no longer identical to the original - like your hands. The fallout when this crucial concept is ignored can have devastating effects, as seen with Thalidomide.
The separation and analysis of chiral molecules is of great importance since the enantiomers wildly differ in their biological properties. Further the environments, in which they operate, biological systems, are also chiral. That makes the situation more complex.
Chiral chromatography has advanced to turn into the most preferred technique for the determination of enantiomeric purity as well as separation of pure enantiomers both on analytical and preparative scale. This includes the use of techniques viz. chiral GC, HPLC, SFC, CE and TLC. The result of a literature survey done identifies HPLC-based chiral assays as the most dominating technology in use. Pharmaceutical companies employ these techniques in chiral drug discovery and development.
The intent of this presentation is to reflect upon the prominence, challenges, chiral stationary phases, and pharmaceutical application of HPLC for the separation and analysis of chiral drugs.
As the number and complexity of chiral drugs and biologically active compounds increases, there is a growing need to advance chiral separation techniques. The number one way to separate chiral compounds is with HPLC using chiral stationary phases. This editorial web seminar presented by Zachary S. Breitbach of Abbvie, will address the need for improved chiral separations and discuss approaches for screening chiral columns, as well as new advancements in chiral column technology that lead to high efficiency and ultrafast chiral separations.
Chirality MIT RES.TLL-004 Concept Vignettes View the complete course: · Instructor: Brad Pentelute