Valliappan Kannappan

Episode 5: From Generative Stereochemistry to Autonomous Chiral Discovery

Author(s):
AI in Chirality
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November 10, 2026

From Generative Stereochemistry to Autonomous Chiral Discovery Summary A closed loop for chirality would design a stereochemically defined molecule, plan a route, execute it, measure enantiomeric excess, and decide what to run next. Every link now exists somewhere in the literature. None have been joined end to end for a stereochemical objective. The weakest links …

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Episode 4: AI for making and separating the right stereoisomer

Author(s):
AI in Chirality
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November 10, 2026

Where chirality aware machine learning has actually been tested against experiment Summary This is the part of the field with a genuine experimental track record. Models have proposed catalysts, enzyme variants, reactions and resolving agents that were then made and tested, and that worked. A model designed resolution screen resolved three of six previously unseen …

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Chirality: Three Nobel Prizes and the Mysteries Still Unsolved

Author(s):
Chiral science, Nobel Prize
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October 25, 2026

Prelude Few ideas in chemistry have been honoured so consistently by the Nobel committee. The prizes of 2001, 2021 and 2026 each rewarded a different way of making one mirror image in preference to the other: first through chiral metal catalysts, then through small organic molecules, and most recently through reactions that amplify their own …

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Episode 3: Predicting What Chirality Does

Author(s):
AI in Chirality
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November 10, 2026

Recognising two stereoisomers is one problem; predicting how they diverge is a much harder one Summary The reason to build chirality-aware models is not to classify stereocentres but to predict consequences: which enantiomer binds, which is cleared faster, which carries the toxicity. This is where the evidence base is thinnest. Chirality-aware architectures win on benchmark …

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When Chemistry Chose a Hand: The Kagan–Soai Story and the 2026 Nobel Prize in Chemistry

Author(s):
Chiral science
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October 19, 2026

Non-Linear Effects, Asymmetric Autocatalysis and the Amplification of Chirality A prize for asymmetry that feeds itself On 7 October 2026 the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry to Henri B. Kagan (Université Paris-Sud) and Kenso Soai (Tokyo University of Science) “for the discovery of non-linear effects and autocatalysis in asymmetric …

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Episode 2: AI That Sees, Measures, and Assigns Chirality

Author(s):
AI in Chirality
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November 10, 2026

From interpretive expertise to multimodal analytical inference Summary Determining a molecule’s configuration, or resolving its enantiomers on a column, has traditionally meant comparing experimental data against a computed reference  a process gated by quantum chemistry and by expert judgement. Machine learning is now compressing that comparison from hours to seconds and, in chiral chromatography, is …

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Episode 1: Teaching Machines Molecular Handedness

Author(s):
AI in Chirality
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November 10, 2026

Why chirality has to be built into a molecular representation before any model can learn it Episode 1 of 5 Summary Two enantiomers can differ by an order of magnitude in potency, yet to most molecular machine learning models they are the same molecule. This is not a data problem that more training examples will …

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Atropisomerism in Action: The Sotorasib Story

Author(s):
Atropisomers, Chiral science, Chirality
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August 24, 2026

When a Biaryl Bond Became a Drug-Design Advantage—and a Development Challenge Introduction: What if a “rotatable bond” could influence the fate of a drug? I recently came across a fascinating perspective written by scientists directly involved in the development of sotorasib, a KRAS G12C inhibitor exhibiting atropisomerism. Their article, “Addressing Atropisomerism in the Development of …

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Episode 5: Defending the Method: Regulatory Expectations and Where the Field Is Heading

Author(s):
Chiral Chromatography, Chiral HPLC Analysis, Chiral science
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September 20, 2026

How chiral methods and isolated standards are justified in a dossier, and a calibrated view of the future The regulatory position on stereochemical purity Regulators have treated stereochemistry as a quality and development issue for decades, and the core position has been stable even as the vocabulary evolved. FDA’s 1992 stereoisomer guidance requires that the …

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Episode 4: From Peak to Standard: Preparative Isolation of Chiral Impurities

Author(s):
Chiral Chromatography, Chiral HPLC Analysis, Chiral science
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September 20, 2026

“Turning an analytical separation into an isolated, characterised, defensible impurity standard” Why isolate a chiral impurity at all Analytical scientists ask for isolated chiral impurities when a chromatogram is no longer enough. The reasons are concrete: structural elucidation of an unknown peak, preparation of a reference standard, response-factor determination, qualification under ICH impurity expectations, forced-degradation …

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