#ChiralDrugDiscovery

Episode 5: From Generative Stereochemistry to Autonomous Chiral Discovery

From Generative Stereochemistry to Autonomous Chiral Discovery Summary A closed loop for chirality would design a stereochemically defined molecule, plan a route, execute it, measure enantiomeric excess, and decide what to run next. Every link now exists somewhere in the literature. None have been joined end to end for a stereochemical objective. The weakest links …

Episode 5: From Generative Stereochemistry to Autonomous Chiral Discovery Read More »

Episode 3: Predicting What Chirality Does

Recognising two stereoisomers is one problem; predicting how they diverge is a much harder one Summary The reason to build chirality-aware models is not to classify stereocentres but to predict consequences: which enantiomer binds, which is cleared faster, which carries the toxicity. This is where the evidence base is thinnest. Chirality-aware architectures win on benchmark …

Episode 3: Predicting What Chirality Does Read More »