What modern chiral separation science can do now, and where the honest limits still lie The present technology landscape The most useful framing of the current landscape is that it is no longer sensible to ask, in the abstract, whether chiral HPLC or chiral SFC is “the best” approach. Modern laboratories operate with both, or …
Episode 3: State of the Art: Selectors, SFC, Speed, and Sensible Automation Read More »
From a structural diagnosis of the analyte to a defendable, robust, lifecycle-ready method Start with the molecule, not the column catalogue A credible chiral method does not begin with random column screening. It begins with a short structural diagnosis of the analyte and the likely impurity set. The pKa values indicate whether the analyte is …
Episode 2: Developing a Chiral HPLC Method: A Structure-Led Workflow Read More »
The pharmaceutical meaning of chirality, the real impurity space, and where chiral HPLC fits The pharmaceutical meaning of chirality Chirality matters in drug development for a simple reason. Biological systems are chiral, so the body does not experience two stereoisomers as the same molecule. FDA stated this explicitly in its landmark 1992 stereoisomer guidance, noting …
Episode 1: Why Chirality Still Matters: Stereochemistry as a Critical Quality Attribute Read More »