Chirality – Chiralpedia

Episode 1: Why Chirality Still Matters: Stereochemistry as a Critical Quality Attribute

Leave a Comment / Chiral HPLC Analysis, Chiral science, Chiral Separation, Chirality / By Valliappan Kannappan and Chandramouli R / #chiral_chromatography, #chiral_method-development, #chirality, #chiralpedia / August 2, 2026 August 2, 2026

The pharmaceutical meaning of chirality, the real impurity space, and where chiral HPLC fits The pharmaceutical meaning of chirality Chirality matters in drug development for a simple reason. Biological systems are chiral, so the body does not experience two stereoisomers as the same molecule. FDA stated this explicitly in its landmark 1992 stereoisomer guidance, noting …

Episode 1: Why Chirality Still Matters: Stereochemistry as a Critical Quality Attribute Read More »

Episode 10: Future Directions in Chiral Agrochemistry

Leave a Comment / Chiral Agrochemistry, Chiral science, Chirality / By Valliappan Kannappan and Chandramouli R / #chiral_agrochemistry, #chirality, #chiralpedia / July 7, 2026 July 7, 2026

Introduction Chirality has already transformed how agrochemicals are designed, evaluated, and applied. From the early reliance on racemic formulations to today’s enantiopure products such as metalaxyl-M, the trajectory shows a clear shift toward stereochemistry as a cornerstone of innovation. The future of chiral agrochemistry lies at the intersection of asymmetric synthesis, biocatalysis, computational design, and …

Episode 10: Future Directions in Chiral Agrochemistry Read More »

Germanium 🧬: Beyond Carbon — A Chiralpedia Guide to a New Dimension of Chirality

Leave a Comment / Chiral science, Chirality / By Valliappan Kannappan / #chirality, #chiralpedia, #germnium / April 17, 2026 April 17, 2026

Demonstrates that chirality extends beyond carbon into heavier elements Introduction: Beyond Carbon-Centered Chirality Chirality is one of the most fundamental concepts in chemistry, typically introduced through tetrahedral carbon atoms bearing four different substituents. However, chirality is not limited to carbon—it extends across the periodic table. Germanium, a Group 14 element positioned below silicon, presents a …

Germanium 🧬: Beyond Carbon — A Chiralpedia Guide to a New Dimension of Chirality Read More »

Episode 5: Beyond Bias: Toward Chiral Intelligence

Leave a Comment / AI, Chiral science, Chirality / By Valliappan Kannappan and Chandramouli R / #AI, #chiral_drugs, #chirality, #chiralpedia / January 8, 2026 June 5, 2026

❓ Can AI truly be intelligent if it is stereo-blind? 🌀 On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly …

Episode 5: Beyond Bias: Toward Chiral Intelligence Read More »

Episode 4: Fixing the Bias: Data, Models and Generative Constraints

Leave a Comment / AI, Chiral science, Chirality / By Valliappan Kannappan and Chandramouli R / #AI, #chiral_drugs, #chirality, #chiralpedia / January 4, 2026 June 5, 2026

❓ How do we move from recognizing chiral bias to responsibly fixing it? On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is …

Episode 4: Fixing the Bias: Data, Models and Generative Constraints Read More »

Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline?

Leave a Comment / AI, Chiral science, Chirality / By Valliappan Kannappan and Chandramouli R / #AI, #chiral_drugs, #chirality, #chiralpedia / January 1, 2026 June 5, 2026

“When molecules have two hands but AI only sees one.” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in …

Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline? Read More »

Episode 2: Why Chirality Confuses Machines?

Leave a Comment / AI, Chiral science, Chirality / By Valliappan Kannappan and Chandramouli R / #AI, #chiral_bias, #chiral_drugs, #chirality, #chiralpedia / December 29, 2025 June 5, 2026

“AI isn’t blind—just stereo-sloppy” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in …

Episode 2: Why Chirality Confuses Machines? Read More »

Episode 1: The Promise and the Paradox: AI That Miss the Mirror

2 Comments / AI, Chiral science, Chirality / By Valliappan Kannappan and Chandramouli R / #AI, #chiral_bias, #chiral_drugs, #chirality, #chiralpedia / December 26, 2025 June 5, 2026

“When algorithms forget the mirror, molecules lose their meaning” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the …

Episode 1: The Promise and the Paradox: AI That Miss the Mirror Read More »

🧭 The Molecular Grammar of Medicines: Isomerism, Chirality, and Stereochemical Relationships Explained

Leave a Comment / Chiral science, Chirality, Drug stereochemistry, Stereochemistry / By Valliappan Kannappan / #chirality, #chiralpedia, #isomerism, #Isomers, #stereoisomeric_drugs, #stereoisomers / November 7, 2025 November 12, 2025

“Where molecules speak, stereochemistry gives them meaning“ In pharmaceuticals, structure is language — and stereochemistry is its grammar. The way atoms arrange in 3D space shapes how drugs work, how they are regulated, and how safe they are. This Chiralpedia tutorial simplifies the molecular “grammar” behind drug behavior and innovation. When Structure Speaks Every drug …

🧭 The Molecular Grammar of Medicines: Isomerism, Chirality, and Stereochemical Relationships Explained Read More »

The Hidden Chirality in Drug Metabolites: A metabolic blind spot

Leave a Comment / Chiral science, Chirality, Drug stereochemistry / By Valliappan Kannappan / #chiral_analysis, #chiral_drugs, #chiral_metabolites, #chirality, #chiralpedia / October 25, 2025 October 26, 2025

“Chirality isn’t hidden — we just stopped looking closely enough” The Unseen Journey After the Dose: 💊 When a patient swallows a drug, the journey is far from over. Sometimes, the real chiral story begins after the dose. The drug molecule meets a series of enzymes — oxidases, reductases, transferases — each capable of transforming …

The Hidden Chirality in Drug Metabolites: A metabolic blind spot Read More »

An excellent and insightful article highlighting how stereochemistry influences fungicide efficacy, environmental fate, and sustainability in modern agriculture. Appreciation to…

An excellent and well-articulated article highlighting the significance of chirality in herbicides with impressive scientific depth and practical relevance. Truly…

Thank you for your kind words. It was a privilege to highlight Prof. Ellman’s remarkable contributions—truly a legacy that continues…

A wonderful and insightful write-up! My sincere appreciation to Dr. Valliappan for elegantly highlighting the noble and impactful research of…

I share your optimism — refinement will come. But improvement isn’t automatic. If the data and benchmarks remain stereo-sloppy, models…

Absolutely — thank you for that thoughtful insight. Chiral literacy isn’t a computational luxury; it’s a scientific necessity. If our…

This is a vital topic very well articulated by authors. The importance of this chiral literacy needs to be instilled…

Presumably the situation will improve & this inconsistency will inevitably be overcome with further development & associated refinement.

Fascinating read on asymmetric synthesis breakthroughs! The article brilliantly showcases how P4 catalysts are revolutionizing enantioselective reactions – a game-changer…

Good article. Please do take seminar for chiral chromatography.