Chandramouli R

Episode 2: Stereoselectivity and Biological Activity in Pesticides

Author(s):
Chiral Agrochemicals, Chiral science
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June 2, 2026

?? “When Mirror Images Decide Between Protection and Toxicity.” Introduction Pesticides are essential tools in modern agriculture, protecting crops from insects, weeds, and pathogens. Many of these compounds are chiral, meaning they exist as two or more non-superimposable mirror-image forms called enantiomers. Enantiomers often exhibit very different biological activities, toxicities, and environmental behaviors. Understanding these …

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Episode 1: Introduction to Chirality in Agrochemicals

Author(s):
Chiral science
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June 1, 2026

What happens when ????????? ????? ???? ???????? Introduction Chirality, the property of a molecule that makes it non-superimposable on its mirror image, is a crucial consideration in agrochemistry. Agrochemicals such as pesticides, herbicides, and fungicides often contain one or more stereogenic centers. The two enantiomers of a chiral molecule can behave very differently in biological …

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Episode 5: Beyond Bias: Toward Chiral Intelligence

Author(s):
AI, Chiral science, Chirality
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June 5, 2026

❓ Can AI truly be intelligent if it is stereo-blind? ? On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly …

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Episode 4: Fixing the Bias: Data, Models and Generative Constraints

Author(s):
AI, Chiral science, Chirality
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June 5, 2026

❓ How do we move from recognizing chiral bias to responsibly fixing it? On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is …

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Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline?

Author(s):
AI, Chiral science, Chirality
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June 5, 2026

“When molecules have two hands but AI only sees one.” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in …

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Episode 2: Why Chirality Confuses Machines?

Author(s):
AI, Chiral science, Chirality
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June 5, 2026

“AI isn’t blind—just stereo-sloppy” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in …

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Episode 1: The Promise and the Paradox: AI That Miss the Mirror

Author(s):
AI, Chiral science, Chirality
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June 5, 2026

“When algorithms forget the mirror, molecules lose their meaning” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the …

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Part 10: Stereochemistry in Pharmaceutical Sciences – Current Trends and Future Directions

Author(s):
Stereochemistry
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June 2, 2026

“Beyond today – emerging trends shaping the future of stereochemistry in pharma” Introduction The landscape of stereochemistry in pharmaceutical sciences continues to evolve with scientific and technological advances. This final part looks at emerging trends and future challenges. These include: – New developments in asymmetric catalysis, such as organocatalysts (MacMillan/List catalysts) that have expanded the …

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Part 9: Stereochemistry in Drug Discovery and Development

Author(s):
Stereochemistry
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June 2, 2026

“From hit to lead to medicine – where stereochemistry shapes every stage of discovery” Introduction Stereochemistry is not only crucial in the final stages of drug production – it plays a significant role right from the discovery and lead optimization phases. In this part, we consider how medicinal chemists account for chirality when designing compounds …

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Part 8: Stereochemistry in Biologics and Natural Products

Author(s):
Stereochemistry
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June 2, 2026

“Nature’s stereochemists – chirality in biologics, peptides, and natural products” Introduction Stereochemistry is inherent in biological macromolecules and natural products. This part explores chirality beyond small synthetic drugs – specifically, in biologics (peptides, proteins, nucleic acids) and in natural product-derived drugs. We examine how nature’s biosynthetic machinery imparts stereochemistry with high fidelity (e.g., enzymes produce …

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