Chandramouli R

Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline?

Leave a Comment / AI, Chiral science, Chirality / By / , , , / June 5, 2026

“When molecules have two hands but AI only sees one.” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in …

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Episode 2: Why Chirality Confuses Machines?

Leave a Comment / AI, Chiral science, Chirality / By / , , , , / June 5, 2026

“AI isn’t blind—just stereo-sloppy” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in …

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Episode 1: The Promise and the Paradox: AI That Miss the Mirror

2 Comments / AI, Chiral science, Chirality / By / , , , , / June 5, 2026

“When algorithms forget the mirror, molecules lose their meaning” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the …

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Part 10: Stereochemistry in Pharmaceutical Sciences – Current Trends and Future Directions

Leave a Comment / Stereochemistry / By / , , / June 2, 2026

“Beyond today – emerging trends shaping the future of stereochemistry in pharma” Introduction The landscape of stereochemistry in pharmaceutical sciences continues to evolve with scientific and technological advances. This final part looks at emerging trends and future challenges. These include: – New developments in asymmetric catalysis, such as organocatalysts (MacMillan/List catalysts) that have expanded the …

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Part 9: Stereochemistry in Drug Discovery and Development

Leave a Comment / Stereochemistry / By / , , / June 2, 2026

“From hit to lead to medicine – where stereochemistry shapes every stage of discovery” Introduction Stereochemistry is not only crucial in the final stages of drug production – it plays a significant role right from the discovery and lead optimization phases. In this part, we consider how medicinal chemists account for chirality when designing compounds …

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Part 8: Stereochemistry in Biologics and Natural Products

Leave a Comment / Stereochemistry / By / , / June 2, 2026

“Nature’s stereochemists – chirality in biologics, peptides, and natural products” Introduction Stereochemistry is inherent in biological macromolecules and natural products. This part explores chirality beyond small synthetic drugs – specifically, in biologics (peptides, proteins, nucleic acids) and in natural product-derived drugs. We examine how nature’s biosynthetic machinery imparts stereochemistry with high fidelity (e.g., enzymes produce …

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Part 7: Analytical Techniques for Stereochemistry

Leave a Comment / Stereochemistry / By / , , , / June 2, 2026

“Measuring handedness – tools and techniques that bring chirality into focus” Introduction Ensuring the correct stereochemistry and measuring stereochemical purity is a crucial aspect of pharmaceutical quality control and research. This part covers the major analytical techniques used to distinguish and quantify enantiomers and diastereomers in drug substances and products. Key techniques include: We’ll discuss …

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Part 6: Resolution of Enantiomers

Leave a Comment / Stereochemistry / By / , , / June 2, 2026

“Separating the inseparable: how chemists resolve mirror-image molecules.” Introduction Despite advances in asymmetric synthesis (Part 5), sometimes we still end up with a racemic mixture of enantiomers. When direct stereoselective routes are impractical, chemists must separate the enantiomers – a process known as resolution. This part examines classical and modern methods for resolving enantiomers, their …

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Part 5: Stereoselective and Stereospecific Synthesis

Leave a Comment / Stereochemistry / By / , , / June 2, 2026

“Crafting molecules with precision – the art of stereochemical synthesis” Introduction Having seen why the correct stereochemistry is crucial for drug efficacy and safety, the next challenge is how to obtain the desired stereoisomer. This part covers strategies and methods in stereoselective and stereospecific synthesis. We clarify the terminology: a stereoselective reaction preferentially yields one …

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Part 4: Stereochemistry in Drug Action and Pharmacology

Leave a Comment / Stereochemistry / By / , / June 2, 2026

“Why one enantiomer heals while the other may harm – the pharmacology of chirality” Introduction Chirality doesn’t just influence drug properties in theory – it has very real consequences in pharmacology. In this section, we explore how stereochemistry affects drug action at multiple levels: pharmacodynamics (drug-receptor interactions) and pharmacokinetics (absorption, distribution, metabolism, excretion). We will …

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