Valliappan Kannappan

As the study of chirality enters its next phase, it remains at the forefront of scientific exploration, bridging disciplines such as chemistry, biology, pharmacology, and material science. The journey from its foundational discoveries to the transformative breakthroughs in asymmetric synthesis and pharmaceutical applications has established chirality as a fundamental concept in understanding and manipulating molecular …

Part 5. The Future of Chirality: Challenges and Innovations Read More »

The intersection of chirality and medicine is a compelling narrative that reveals both the promise and peril of molecular asymmetry. From its earliest applications in pharmacology to the tragic consequences of overlooking enantiomeric differences, the role of chirality in medicine underscores the profound impact of stereochemistry on human health. This chapter delves into the breakthroughs, …

P3. Chirality in Medicine: From Discovery to Disaster Read More »

Lead The story of chirality gained momentum in the late 19th century, as chemists began unraveling the structural principles behind molecular asymmetry. Pioneers like Jacobus Henricus van’t Hoff and Joseph Achille Le Bel laid the groundwork for modern stereochemistry by introducing three-dimensional molecular models. Their work bridged theoretical chemistry and practical applications, setting the stage …

P2. The Building Blocks of Stereochemistry Read More »

Lead Chirality – a concept rooted in the mirror-image asymmetry observed in nature – stands as a cornerstone of chemistry and pharmaceutical sciences. This journey begins in the early 19th century, where the interplay of physics, chemistry, and biology unveiled the mysterious world of chiral molecules. These pioneering explorations profoundly changed our understanding of molecular …

P1. The Origins of Chirality: From Light to Life Read More »