#chiralpedia

Asymmetric Synthesis in Industry: From Lab to Market

2 Comments / Asymmetric Synthesis / By / , , / June 2, 2026

Introduction Asymmetric synthesis is a cornerstone of industrial chemistry, enabling the production of enantiomerically pure compounds that are essential in various sectors. Its importance lies in the ability to produce specific enantiomers that exhibit desired biological activities or material properties. Asymmetric synthesis is the process of turning a non-chiral starting material into a chiral product. …

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Harnessing Computational Methods in Asymmetric Synthesis

7 Comments / Asymmetric Synthesis / By / , , / June 2, 2026

Introduction Asymmetric synthesis is a critical area of chemistry that relies heavily on the precise control of molecular chirality. While experimental methods have traditionally driven advancements in this field, the integration of computational chemistry has significantly enhanced our understanding and capabilities. Computational approaches offer several advantages, including the ability to model complex systems, predict reaction …

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Recent Advances in Catalytic Asymmetric Synthesis

2 Comments / Asymmetric Synthesis, Chiral synthesis, Enantioselective synthesis / By / , , / June 2, 2026

Introduction Catalysis is a cornerstone of modern chemistry, playing a pivotal role in asymmetric synthesis. By facilitating the formation of chiral molecules with high enantioselectivity, catalytic asymmetric synthesis has revolutionized the production of pharmaceuticals, agrochemicals, and fine chemicals. The development of efficient chiral catalysts has enabled chemists to produce enantiomerically pure compounds more reliably and …

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Understanding the Fundamentals of Asymmetric Synthesis

2 Comments / Asymmetric Synthesis, Chiral synthesis, Enantioselective synthesis / By / , , , , / June 2, 2026

Introduction Chirality is a fundamental concept in chemistry that plays a crucial role in the structure and function of molecules. Derived from the Greek word for “hand,” chirality refers to the geometric property of a molecule that makes it non-superimposable on its mirror image. This characteristic is significant in various fields, including pharmaceuticals, where the …

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Chirality and You: Understanding and Appreciating Molecular Handedness

2 Comments / Chirality / By / , , / June 2, 2026

Lead Chirality, or molecular handedness, is a fundamental concept in chemistry and biology that affects many aspects of our daily lives. From the structure of DNA to the effectiveness of medications, chirality plays a crucial role in how molecules interact and function. This blog aims to make the concept of chirality accessible and relevant, encouraging …

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Introduction to Chirality: Understanding the Basics

Leave a Comment / Chirality / By / , , / June 2, 2026

Lead Chirality, derived from the Greek word “cheir” meaning hand, is a fundamental concept in chemistry that describes an object’s property of being non-superimposable on its mirror image. This property is not just an abstract mathematical idea but has profound implications in various scientific fields, particularly chemistry and biology. Understanding chirality is essential for comprehending …

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Protein-based CSPs

Leave a Comment / Chiral separation and analysis / By / , / July 5, 2024

Lead Proteins are complex, high-MW biopolymers composed of L-amino acids and possess ordered 3D-structure. They are known to bind /interact  stereoselectively with small molecules  reversibly, making them extremely versatile CSPs for chiral separation of drug molecules.   Number of CSPs has been developed by immobilizing proteins. These type of CSPs operate under RP-mode; (phosphate buffer …

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Rediscovery of stereochemistry

Leave a Comment / Chirality, Drug stereochemistry / By / , , , / July 5, 2024

Stereochemistry, in particular chirality, is known to us as early as 1809, when Malus, Arago and Biot discovered plane polarized light and its characteristics. It is observed that during 1950s to the 1970s, the “Golden Age” of drug discovery & development, stereochemistry was largely ignored resulting in approximately 57% of pharmaceuticals being marketed as racemates …

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Levamisole

Leave a Comment / Chirality / By / , , , / July 5, 2024

Levamisole is used as anthelmintic agent to get rid of the intestinal worms. It is (S)-(-)-enantiomer of tetramisole. This drug is used in veterinary to treat hookworm infections.  Levamisole also finds therapeutic application in the treatment of colon cancer when given in conjunction with fluorouracil.   Chirality and biological activity Tetramisole carries one chiral stereogenic …

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Beta-Blockers

Leave a Comment / Chirality / By / , , , / July 5, 2024

Beta blockers, also spelled β-blockers, used as antihypertensive agents (lowering blood pressure), represent a class of chiral drugs that are marketed as racemates since the distomer exhibits no undesirable adverse effects. Three most important β-blockers viz. propranolol, atenolol, and metoprolol are marketed as racemic mixture. Chirality and biological activity β-blockers are aryloxy propanolamines with one stereogenic …

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