Valliappan Kannappan

Unconventional Approaches in Chiral Resolution: New Horizons

Leave a Comment / Chiral resolution, Chiral Separation / By / , , / June 2, 2026

Lead Chiral resolution has been an essential process in various industries, particularly pharmaceuticals, where separating enantiomers is critical for drug efficacy and safety. Traditional techniques such as chromatography, crystallization, and kinetic resolution have served as the backbone of chiral separation. However, these methods can be time-consuming, costly, and inefficient, especially at large scales. As industries …

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Innovations in Membrane and Kinetic Resolution for Chiral Separation

Leave a Comment / Chiral resolution, Chiral Separation / By / , , / June 2, 2026

Lead Chiral resolution techniques have long been a cornerstone in pharmaceutical and chemical industries, where separating enantiomers is crucial for producing safe and effective products. Among the most promising methods are membrane-based and kinetic resolution techniques, both of which have seen significant advancements in recent years. These methods are becoming increasingly relevant as industries seek …

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Breaking Down the Methods: Chromatography and Crystallization in Chiral Resolution

Leave a Comment / Chiral resolution, Chiral Separation / By / , , / June 2, 2026

Lead Chiral resolution, the process of separating enantiomers, is crucial in various fields such as pharmaceuticals, agrochemicals, and food industries. Chirality, as discussed in previous sections, involves molecules that are mirror images of each other but cannot be superimposed. This seemingly subtle difference leads to enantiomers having different biological, chemical, and pharmacological properties. The importance …

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The Fundamentals of Chiral Resolution: Why Chirality Matters

Leave a Comment / Chiral resolution, Chiral Separation / By / , , / June 2, 2026

Lead Chirality, a term derived from the Greek word “cheir,” meaning hand, is a fundamental concept in chemistry and biology that refers to the geometric property of an object not being superimposable on its mirror image. Much like our hands, chiral molecules exist in pairs known as enantiomers, which are mirror images of each other …

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Chiral Bioequivalence – An Explainer  

Leave a Comment / Chiral science, Chirality / By / , , / June 2, 2026

Introduction Chirality, or “handedness,” is the unique property of molecules that exist as non-superimposable mirror images, known as enantiomers. Drugs that exhibit handedness are referred to as chiral drugs. Chiral medications consisting of an equal (1:1) mixture of enantiomers are called Racemic drugs. In drug development, chirality is incredibly important because most biological molecules, like …

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Chiral Switch: Unlocking the Potential of Single Enantiomers

Leave a Comment / Chiral science, Chirality / By / , / August 17, 2025

Synopsis Welcome to an exploration of Chiral Switch!!! Chiral switching revolutionizes the pharmaceutical landscape by transforming racemic drugs into their more effective single-enantiomer forms, enhancing therapeutic efficacy and reducing side effects This blog post delves into the intriguing realm of chiral switches, presenting key concepts such as chiral switch strategies, their advantages, and the regulatory …

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Chiral Drugs: A twisted tale in pharmaceuticals

Leave a Comment / Chiral science / By / , , / January 18, 2025

Synopsis Chiral drugs, those fascinating chemical compounds existing as mirror-image pairs or enantiomers, exhibit distinct biological properties. This post provides a comprehensive overview of chiral drugs, presenting key concepts through a visually engaging mind maps. It covers chirality’s historical roots and stereochemical nomenclature, delves into the specialized discipline of chiral pharmacology, and presents drug toxicity …

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The Future of Asymmetric Synthesis: Trends and Innovations”

1 Comment / Asymmetric Synthesis / By / , , / June 2, 2026

Introduction Asymmetric synthesis has made significant strides in recent decades, becoming a crucial component of pharmaceutical, agrochemical, and fine chemical industries. The development of chiral catalysts and the understanding of stereoselective reactions have enabled the production of enantiomerically pure compounds on an industrial scale. This blog explores the future perspectives in chiral asymmetric synthesis, focusing …

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Asymmetric Synthesis in Industry: From Lab to Market

2 Comments / Asymmetric Synthesis / By / , , / June 2, 2026

Introduction Asymmetric synthesis is a cornerstone of industrial chemistry, enabling the production of enantiomerically pure compounds that are essential in various sectors. Its importance lies in the ability to produce specific enantiomers that exhibit desired biological activities or material properties. Asymmetric synthesis is the process of turning a non-chiral starting material into a chiral product. …

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Harnessing Computational Methods in Asymmetric Synthesis

7 Comments / Asymmetric Synthesis / By / , , / June 2, 2026

Introduction Asymmetric synthesis is a critical area of chemistry that relies heavily on the precise control of molecular chirality. While experimental methods have traditionally driven advancements in this field, the integration of computational chemistry has significantly enhanced our understanding and capabilities. Computational approaches offer several advantages, including the ability to model complex systems, predict reaction …

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