Atropisomerism
Paired Concept:
Conformational Isomerism
Definition: Stereoisomerism due to hindered rotation that creates isolable enantiomers.
Context: Drug candidates may have atropisomeric axes requiring control and specification.
Example: Atropisomeric biaryl kinase inhibitors.
Related Terms: Axial Chirality, Barrier to Rotation.
Reference: Clayden et al. (2012).
