( An Open Knowledge Base for Microbial Natural Products )
Natural Products Atlas (NPAtlas) is an open-access database of microbially derived natural products, providing a centralized resource for exploring the chemical diversity of compounds from bacterial and fungal sources. Users can search compounds by structure, substructure, name, molecular properties, and biological origin, while interactive tools enable exploration of natural-product chemical space and structural relationships.
For chiral science, NPAtlas is particularly valuable because its curation includes configurational information and structural revisions involving chiral centers. It therefore provides a useful resource for exploring stereochemically rich natural-product scaffolds, comparing related structures, and investigating structural diversity in complex natural products.
| Field | Details |
| Developer | Linington Research Group, Simon Fraser University, with an international team of contributors |
| Category | Cheminformatics |
| Primary Applications | Natural-product discovery; structure and substructure searching; chemical-space exploration; compound classification; dereplication; structural-series analysis; taxonomy and origin analysis |
| Chirality Relevance | Provides curated stereochemical information for natural products, including structural revisions and configurational assignments involving chiral centers. Particularly useful for exploring stereochemically rich natural-product scaffolds and tracking structural reassignment. |
| Platform | Web-based database and interactive chemical-space exploration platform |
| License | Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) |
| Key Features | Structure, substructure and similarity searching; molecular-property searches; taxonomic searching; chemical-space visualization; structural clustering; compound-class annotations; bioactivity and physicochemical information; downloadable datasets; RESTful API; tutorials and interactive discovery tools |
| Website | https://www.npatlas.org/?utm_source=chatgpt.com |
| Operating System | Web-based — OS independent (Windows, macOS, Linux) |
| Chiralpedia Editorial Note | NPAtlas is more than a natural-products catalogue: its combination of curated molecular structures, chemical-space analysis, and attention to structural reassignment makes it a valuable resource for researchers investigating complex and stereochemically rich natural products. Its downloadable datasets and API also make it relevant to computational and AI/ML workflows in natural-products research. |
