Hashed (Wedge-Dash Representation)
Definition: A visual notation in molecular drawings where hashed bonds represent bonds going behind the plane of the paper.
Context: Used to depict stereochemistry in three-dimensional projections.
Example: Hashed bond to indicate the backward substituent in Fischer or wedge projections.
Related Terms: Wedged; Fischer Projection; Newman Projection.
Reference: Morrison & Boyd. Organic Chemistry. Prentice Hall, 1992.
Helicity (P/M)
Screw sense of helical molecules designated P (plus) or M (minus).
Context: Describes helicenes and protein helices relevant to binding.
Example: P-helicene vs M-helicene.
Related Terms: Axial Chirality, Planar Chirality.
Reference: IUPAC Gold Book.
Horeau Method
Indirect determination of ee via formation of meso/dl diesters.
Context: Historical approach for ee estimation.
Example: Horeau’s diacid anhydrides with alcohols.
Related Terms: Optical Purity, CDA.
Reference: Horeau, Tetrahedron (1961).