#chiral_drugs

Episode 4: Fixing the Bias: Data, Models and Generative Constraints

Leave a Comment / Chiral science / By / , , , / January 5, 2026

❓ How do we move from recognizing chiral bias to responsibly fixing it? On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in chiral systems, intuition must always yield to structure. The earlier parts …

Episode 4: Fixing the Bias: Data, Models and Generative Constraints Read More »

Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline?

Leave a Comment / Chiral science / By / , , , / January 5, 2026

“When molecules have two hands but AI only sees one.” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in chiral systems, intuition must always yield to structure. The first two parts of this …

Episode 3: When Algorithms Miss the Mirror: How Chiral Blind Spots Break the Pipeline? Read More »

Episode 2: Why Chirality Confuses Machines?

Leave a Comment / Chiral science / By / , , , , / January 5, 2026

“AI isn’t blind—just stereo-sloppy” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in chiral systems, intuition must always yield to structure. The first episode argued that many AI models in drug discovery are …

Episode 2: Why Chirality Confuses Machines? Read More »

Episode 1: The Promise and the Paradox: AI That Miss the Mirror

Leave a Comment / Chiral science / By / , , , , / January 5, 2026

“When algorithms forget the mirror, molecules lose their meaning” On Visuals and Stereochemical TruthSome illustrations in this series are generated or assisted by AI to support conceptual understanding. These visuals are intentionally simplified and should not be read as stereochemically rigorous or chemically exact representations. Wherever stereochemical fidelity matters, it is addressed explicitly in the discussion—because in chemistry, especially in chiral systems, intuition must always yield to structure. Artificial intelligence is now everywhere in drug …

Episode 1: The Promise and the Paradox: AI That Miss the Mirror Read More »

Chiral Drug Engineering: Building Safer, Smarter, and More Selective Medicines

Leave a Comment / Chiral science / By / , , , , , / November 25, 2025

Where a molecule’s handedness meets clever engineering—shaping safer, more precise, and more effective medicines. Introduction: Why Chirality Matters in Drug Engineering In the world of drug design, a subtle twist in molecular geometry can change everything. Two molecules may share the same atoms and bonding pattern yet behave like entirely different substances simply because they are arranged as non-superimposable mirror images—enantiomers. This property, known as chirality, is one of the most critical yet nuanced dimensions …

Chiral Drug Engineering: Building Safer, Smarter, and More Selective Medicines Read More »

The Hidden Chirality in Drug Metabolites: A metabolic blind spot

Leave a Comment / Chiral science, Chirality, Drug stereochemistry / By / , , , , / October 26, 2025

“Chirality isn’t hidden — we just stopped looking closely enough” The Unseen Journey After the Dose: 💊 When a patient swallows a drug, the journey is far from over. Sometimes, the real chiral story begins after the dose. The drug molecule meets a series of enzymes — oxidases, reductases, transferases — each capable of transforming it into one or more metabolites. We often assume these are simply inactive breakdown products, but chemistry rarely plays it …

The Hidden Chirality in Drug Metabolites: A metabolic blind spot Read More »

When Drug Labels Miss the Twist: The regulatory bind spot

Leave a Comment / Chiral Pharmacology, Chiral science, Chirality / By / , , , , , / October 24, 2025

“When chemistry tells two stories, the label should tell both” Drug labels tell us what’s inside — but not always how the molecule twists. And sometimes, that subtle twist changes everything: how a drug acts, how it’s regulated, and even whether it’s safe or addictive. Chirality — the property of handedness in molecules — has always shaped pharmacology. One mirror image of a molecule (an enantiomer) can save lives, while its twin may do little …

When Drug Labels Miss the Twist: The regulatory bind spot Read More »

The Thalidomide Paradox

Leave a Comment / Chirality / By / , , / August 14, 2025

Synopsis The thalidomide tragedy is one of the most infamous episodes in pharmaceutical history—yet its stereochemical secrets are still being unraveled. A fascinating article by Tokunaga E, Yamamoto T, Ito E, and Shibata N., published in Scientific Reports (Nature Research, 2018; https://www.nature.com/articles/s41598-018-35457-6), sheds new light on the phenomenon through the lens of the self-disproportionation of enantiomers, the physical chemistry of chirality. Thalidomide’s tragic past is linked to its two “mirror-image” forms. One form, the S-enantiomer, …

The Thalidomide Paradox Read More »

Episode 10: Future Reflections: How the Story of Chiral Drug Regulation Continues

Leave a Comment / Chiral science, Chirality, Regulatory Affairs / By / , / June 21, 2025

“Approval is not the end of a molecule’s journey – the mirror must be watched, studied, and questioned throughout its life.” Introduction The development and approval of chiral drugs, especially single-enantiomer entities, marked a new chapter in pharmaceutical science. However, approval is only the beginning. Ensuring that a chiral drug continues to behave safely and predictably in the real world demands vigilant post-marketing surveillance, adaptive regulatory frameworks, and constant scientific reevaluation. In this final episode, …

Episode 10: Future Reflections: How the Story of Chiral Drug Regulation Continues Read More »

Episode 9: Challenges on the Horizon: Complex Chirality and Emerging Scientific Questions

Leave a Comment / Chiral science, Chirality, Regulatory Affairs / By / , / June 17, 2025

“As the molecular world grows more intricate, so do the challenges in regulating and understanding chirality.” Introduction While the 1990s and 2000s solidified regulatory frameworks for simple chiral drugs -classic single stereocenter, stable enantiomers –science has since moved into more complex territory. Today, pharmaceutical innovation increasingly deals with molecules featuring multiple stereocenters, dynamic chirality, axial chirality (atropisomerism), and stereochemical instability. These new realities stretch the existing regulatory and scientific paradigms developed for simpler chiral systems. …

Episode 9: Challenges on the Horizon: Complex Chirality and Emerging Scientific Questions Read More »