#chiral_analysis

Part 7: Analytical Techniques for Stereochemistry

“Measuring handedness – tools and techniques that bring chirality into focus” Introduction Ensuring the correct stereochemistry and measuring stereochemical purity is a crucial aspect of pharmaceutical quality control and research. This part covers the major analytical techniques used to distinguish and quantify enantiomers and diastereomers in drug substances and products. Key techniques include: We’ll discuss how these techniques are applied in practice: e.g., during process development, a chiral HPLC method is developed to monitor enantiomeric …

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Chiral Analysis: Mapping the Essentials

Chirality: it’s everywhere – shaping how molecules behave, how medicines work, and even how scents and flavors hit our senses. Prelude In fields like pharmaceuticals and environmental science, understanding chirality isn’t just important – it’s essential. Many biologically active compounds are chiral, and their mirror-image forms (enantiomers) can have dramatically different effects. One enantiomer (the eutomer) might deliver the desired therapeutic benefit, while the other (distomer) could cause unwanted side effects – or worse, toxic …

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