#chiral_analysis – Chiralpedia

The Hidden Chirality in Drug Metabolites: A metabolic blind spot

Leave a Comment / Chiral science, Chirality, Drug stereochemistry / By Valliappan Kannappan / #chiral_analysis, #chiral_drugs, #chiral_metabolites, #chirality, #chiralpedia / October 25, 2025 October 26, 2025

“Chirality isn’t hidden — we just stopped looking closely enough” The Unseen Journey After the Dose: 💊 When a patient swallows a drug, the journey is far from over. Sometimes, the real chiral story begins after the dose. The drug molecule meets a series of enzymes — oxidases, reductases, transferases — each capable of transforming it into one or more metabolites. We often assume these are simply inactive breakdown products, but chemistry rarely plays it …

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Part 7: Analytical Techniques for Stereochemistry

Leave a Comment / Stereochemistry / By Valliappan Kannappan / #chiral_analysis, #chiral_chromatography, #chiral_separation, #chiralpedia / September 21, 2025 October 2, 2025

“Measuring handedness – tools and techniques that bring chirality into focus” Introduction Ensuring the correct stereochemistry and measuring stereochemical purity is a crucial aspect of pharmaceutical quality control and research. This part covers the major analytical techniques used to distinguish and quantify enantiomers and diastereomers in drug substances and products. Key techniques include: We’ll discuss how these techniques are applied in practice: e.g., during process development, a chiral HPLC method is developed to monitor enantiomeric …

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Chiral Analysis: Mapping the Essentials

Leave a Comment / Chiral science / By Valliappan Kannappan / #chiral_analysis, #chirality / April 24, 2025 April 24, 2025

Chirality: it’s everywhere – shaping how molecules behave, how medicines work, and even how scents and flavors hit our senses. Prelude In fields like pharmaceuticals and environmental science, understanding chirality isn’t just important – it’s essential. Many biologically active compounds are chiral, and their mirror-image forms (enantiomers) can have dramatically different effects. One enantiomer (the eutomer) might deliver the desired therapeutic benefit, while the other (distomer) could cause unwanted side effects – or worse, toxic …

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