#stereochemistry

Part 3: Nomenclature and Configuration

“Decoding the rules: how chemists name and navigate molecular twists.” Introduction Correctly describing the stereochemistry of a molecule is as important as understanding it. In this part, we focus on the Cahn–Ingold–Prelog (CIP) system, which provides the rules for unambiguous assignment of absolute configuration at stereocenters (R/S) and for double bond geometry (E/Z) system. We will outline the CIP priority rules step-by-step and demonstrate how to apply them to pharmaceutical molecules. Additionally, we will discuss …

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Part 2: Fundamental Concepts of Chirality

“From left- and right-handedness to life’s molecular signatures—chirality explained” Introduction Building on the overview of chirality, this section delves into core concepts: symmetry elements in molecules, the definitions of enantiomers and diastereomers, and the phenomenon of optical activity. Understanding these fundamentals is essential for grasping how stereochemistry manifests and is measured. We will also explore how chirality is quantified via optical rotation and how instruments like polarimeters help distinguish enantiomers. By the end of this …

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Part 1: Introduction to Stereochemistry

“The 3D language of molecules – why stereochemistry is the hidden key in drug science.” Introduction Stereochemistry is the branch of chemistry concerned with the three-dimensional arrangement of atoms in molecules and how this spatial arrangement influences chemical behavior. The term “chirality” (from the Greek cheir meaning hand) describes the property of an object or molecule that is non-superimposable on its mirror image – much like one’s left and right hands. A molecule that exhibits …

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Mapping Stereochemical Nomenclature: A Chiralpedia Guide

Stereochemistry, the study of spatial arrangements of atoms in molecules, demands a precise and universally accepted nomenclature system. Unlike simple chemical formulas, which only indicate connectivity, stereochemical nomenclature conveys three-dimensional information essential for understanding molecular behavior, biological interactions, and pharmaceutical effects. Several systems have been developed to capture these subtle but critical differences. 🔬✨ Stereochemical Nomenclature System — Now in a Visual Story! Stereochemical naming systems are often tucked away in textbooks 📚, dense and …

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