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The Future of Asymmetric Synthesis: Trends and Innovations”

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Introduction Asymmetric synthesis has made significant strides in recent decades, becoming a crucial component of pharmaceutical, agrochemical, and fine chemical industries. The development of chiral catalysts and the understanding of stereoselective reactions have enabled the production of enantiomerically pure compounds on an industrial scale. This blog explores the future perspectives in chiral asymmetric synthesis, focusing on emerging technologies, interdisciplinary approaches, global impact, and the challenges that lie ahead. Emerging Technologies Green Chemistry Approaches The future …

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Asymmetric Synthesis in Industry: From Lab to Market

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Introduction Asymmetric synthesis is a cornerstone of industrial chemistry, enabling the production of enantiomerically pure compounds that are essential in various sectors. Its importance lies in the ability to produce specific enantiomers that exhibit desired biological activities or material properties. Asymmetric synthesis is the process of turning a non-chiral starting material into a chiral product. This blog explores the industrial applications of chiral asymmetric synthesis, highlighting its critical role in pharmaceuticals, agrochemicals, fine chemicals, and …

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Harnessing Computational Methods in Asymmetric Synthesis

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Introduction Asymmetric synthesis is a critical area of chemistry that relies heavily on the precise control of molecular chirality. While experimental methods have traditionally driven advancements in this field, the integration of computational chemistry has significantly enhanced our understanding and capabilities. Computational approaches offer several advantages, including the ability to model complex systems, predict reaction outcomes, and optimize catalysts. This blog explores the role of computational chemistry in asymmetric synthesis, showcasing its techniques, applications, and …

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Recent Advances in Catalytic Asymmetric Synthesis

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Introduction Catalysis is a cornerstone of modern chemistry, playing a pivotal role in asymmetric synthesis. By facilitating the formation of chiral molecules with high enantioselectivity, catalytic asymmetric synthesis has revolutionized the production of pharmaceuticals, agrochemicals, and fine chemicals. The development of efficient chiral catalysts has enabled chemists to produce enantiomerically pure compounds more reliably and sustainably. This blog explores recent advances in catalytic asymmetric synthesis, highlightinghttps://en.wikipedia.org/wiki/Chirality innovations in chiral catalysts, notable reactions, and their industrial …

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Understanding the Fundamentals of Asymmetric Synthesis

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Introduction Chirality is a fundamental concept in chemistry that plays a crucial role in the structure and function of molecules. Derived from the Greek word for “hand,” chirality refers to the geometric property of a molecule that makes it non-superimposable on its mirror image. This characteristic is significant in various fields, including pharmaceuticals, where the spatial arrangement of atoms within a molecule can drastically affect its biological activity. Basic Concepts Stereoisomerism and Chirality Chirality is …

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Chirality and You: Understanding and Appreciating Molecular Handedness

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Lead Chirality, or molecular handedness, is a fundamental concept in chemistry and biology that affects many aspects of our daily lives. From the structure of DNA to the effectiveness of medications, chirality plays a crucial role in how molecules interact and function. This blog aims to make the concept of chirality accessible and relevant, encouraging readers to appreciate the hidden handedness around and within them and explore the fascinating world of molecular chirality and chiral …

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Introduction to Chirality: Understanding the Basics

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Lead Chirality, derived from the Greek word “cheir” meaning hand, is a fundamental concept in chemistry that describes an object’s property of being non-superimposable on its mirror image. This property is not just an abstract mathematical idea but has profound implications in various scientific fields, particularly chemistry and biology. Understanding chirality is essential for comprehending molecular interactions and their impacts on our daily lives. This first of this blog series delves into the definition, historical …

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Protein-based CSPs

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Lead Proteins are complex, high-MW biopolymers composed of L-amino acids and possess ordered 3D-structure. They are known to bind /interact  stereoselectively with small molecules  reversibly, making them extremely versatile CSPs for chiral separation of drug molecules.   Number of CSPs has been developed by immobilizing proteins. These type of CSPs operate under RP-mode; (phosphate buffer and organic modifiers)   Characteristics of proteins used in commercial CSPs Mechanism Protein polymer remains in twisted form because of the …

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Rediscovery of stereochemistry

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Stereochemistry, in particular chirality, is known to us as early as 1809, when Malus, Arago and Biot discovered plane polarized light and its characteristics. It is observed that during 1950s to the 1970s, the “Golden Age” of drug discovery & development, stereochemistry was largely ignored resulting in approximately 57% of pharmaceuticals being marketed as racemates by the 1980s. Before going further let us examine the stereospecific awareness level that existed during 1980s’. Stereospecific Awareness level  …

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Levamisole

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Levamisole is used as anthelmintic agent to get rid of the intestinal worms. It is (S)-(-)-enantiomer of tetramisole. This drug is used in veterinary to treat hookworm infections.  Levamisole also finds therapeutic application in the treatment of colon cancer when given in conjunction with fluorouracil.   Chirality and biological activity Tetramisole carries one chiral stereogenic center and exists as an enantiomeric pair. The anthelmintic activity resides in the (S)-(-)-enantiomer, levamisole. The (R)- isomer harbors undesirable …

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