Donor-Acceptor (Pirkle)-type CSPs
Lead William H Pirkle developed these CSPs and are based on the ionic or covalent attachment of one enantiomer of an amino acid derivative to aminopropyl silica. Pirkle phases contain π-electron donor or acceptor rings substituted with H-bonding moieties. Donor–acceptor-type CSPs capitalize on synthetic or semi-synthetic chiral low-molecular-weight chiral selectors capable of recognizing chiral analytes by complementary assembly of nonionic attractive interactions. Basic design and types Generally speaking a chiral phase of the Pirkle type …