Chiral Intelligence
Definition: The capacity to understand, interpret, and apply chirality-dependent information across chemical, biological, pharmacological, and regulatory domains.
Context: Chiral intelligence goes beyond recognizing stereochemical descriptors; it integrates molecular structure, biological response, metabolism, safety, and lifecycle decision-making. In pharmaceutical development, chiral intelligence underpins decisions on enantiomer selection, analytical control, regulatory strategy, and clinical risk assessment.
Example: Recognizing that only S-ibuprofen is pharmacologically active, while R-ibuprofen undergoes partial in vivo inversion, and integrating this knowledge into dosing, formulation, and regulatory justification.
Related Terms: Chiral Literacy; Stereo-pharmacology; Eudismic Ratio; Enantiopure; Chiral Drug, Stereochemistry-Aware Models; Enantiomeric Specificity.
Reference: Ariens, E. J. Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology. Medical Research Reviews, 4, 197-236 (1984); Jorner, K., Yu, E., Yoshikawa, N., Jorner, K., Aspuru-Guzik, A., et al. Stereochemistry-aware string-based molecular generation. PNAS Nexus, 4(11), pgaf329 (2025); Reymond, J.-L. Stereochemistry in chemoinformatics and artificial intelligence. Accounts of Chemical Research, 55, 2210-2220 (2022).