Chirality in Materials Science: Designing with Handedness

Lead Chirality, or molecular handedness, is a fundamental concept that has far-reaching implications in various scientific fields. In materials science, chirality plays a crucial role in designing and developing advanced materials with unique properties and functionalities. From enhancing the performance of optical devices to improving the selectivity of catalysts, the application of chirality in materials science is both broad and significant. This blog explores the applications of chirality in materials science, focusing on chiral polymers …

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Chirality in Pharmaceuticals: The Impact of Molecular Handedness on Medicine

Lead Chirality, the property of molecules having non-superimposable mirror images, plays a crucial role in pharmaceuticals. These molecules, referred to as enantiomers, chiral twins, mirror-image, or handed molecules, are crucial in drug design and effectiveness. A significant proportion of chiral drugs on the market are available as racemic mixture. The handedness of these molecules can lead to significantly different biological activities and therapeutic outcomes. This blog delves into the importance of chirality in drug design …

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Chiral Chemistry in Everyday Life: Hidden Handedness Around Us

Introduction Chirality, or molecular handedness, is a fascinating aspect of chemistry that plays a crucial role in the structure and function of many substances we encounter in our daily lives. From the food we eat to the cleaning products we use, chirality influences the properties and effectiveness of numerous everyday items. This blog explores the hidden handedness of chiral chemistry in household products, food and beverages, and other common examples, highlighting their significance and impact. …

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The Chemistry of Taste and Smell: How Chirality Affects Senses

Introduction Chirality, or molecular handedness, plays a pivotal role in the chemistry of taste and smell. From the refreshing scent of mint to the sweet taste of artificial sweeteners, the chirality of molecules influences our sensory experiences in profound ways. In this blog, we will delve into the fascinating world of chiral compounds, exploring how they interact with our sensory receptors and shape the flavors and fragrances we encounter daily. By understanding the chemistry behind …

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Chirality in Nature: From DNA to Snail Shells

Introduction Chirality, derived from the Greek word for “hand,” is a property of asymmetry that is ubiquitous in nature. Just as our hands are mirror images but not identical, many biological molecules exhibit this fascinating characteristic. Chirality is not just a molecular curiosity; it profoundly influences the structure and function of DNA, proteins, and enzymes, as well as various physiological and behavioral traits in plants and animals. In this blog, we will explore the role …

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Molecular Handedness: How Chirality Shapes Molecules

Introduction Molecules can come in two shapes that mirror each other, in the same way as our left and right hands. This attribute, called chirality, can be found in biological molecules like sugars and proteins This property, often referred to as molecular handedness, plays a crucial role in chemistry, biology, and pharmacology. In this article, we will explore the basics of chirality, examine examples of chiral and achiral molecules, and delve into the methods used to …

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Introduction to Chirality: Understanding the Basics

Lead Chirality, derived from the Greek word “cheir” meaning hand, is a fundamental concept in chemistry that describes an object’s property of being non-superimposable on its mirror image. This property is not just an abstract mathematical idea but has profound implications in various scientific fields, particularly chemistry and biology. Understanding chirality is essential for comprehending molecular interactions and their impacts on our daily lives. This first of this blog series delves into the definition, historical …

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Controlling selectivity-Additional factors-3.0 – Column selectivity

Lead Changes in selectivity brought about by modifying the composition of the mobile phase have been discussed up until this point. This method is typically the most practical and economical way to alter selectivity. Alternately, relying on changes in column selectivity to control the separation is a strategy that is typically reserved until all other mobile phase alternatives have been exhausted. As with alterations to the selectivity of the mobile phase, chromatographers should make substantial …

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Harnessing JMP’s Prediction Profiler for Multi-Response Optimization of HPLC Method in Chiral Drug Separation

Synopsis The development of chromatographic methods for the separation of chiral drugs presents a significant challenge, necessitating a comprehensive understanding of the compounds’ chemical properties and the factors influencing their separation. This task is further complicated by the presence of process-related impurities that can disrupt the separation process and compromise the quality of the results. However, the application of advanced statistical tools such as JMP’s Design of Experiments (DoE) and Prediction Profiler can significantly streamline …

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Controlling selectivity-Additional factors-2.0 – temperature

Lead In the earliest posts we saw the how solvent concentration and type are powerful tools for controlling separation and also discussed these variables alone may not be sufficient for achieving the desired sample resolution. In such cases chromatographers may seek to employ other parameters to adjust selectivity viz.. In the last post the discussion was focused on the influence of pH on selectivity. In this blog the focus will be on the effect of …

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