Valliappan Kannappan

The Future of Chiral Resolution: Green Chemistry and Sustainable Practices

Lead Sustainability is becoming an increasingly important consideration across many industries, and chiral resolution is no exception. The separation of enantiomers, essential in pharmaceuticals, agrochemicals, and other sectors, has traditionally relied on methods that consume large amounts of energy, solvents, and other resources. As industries become more aware of the environmental impact of these processes, there is a growing movement toward more sustainable and eco-friendly practices in chiral resolution. 1. Why Sustainability is a Growing …

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Unconventional Approaches in Chiral Resolution: New Horizons

Lead Chiral resolution has been an essential process in various industries, particularly pharmaceuticals, where separating enantiomers is critical for drug efficacy and safety. Traditional techniques such as chromatography, crystallization, and kinetic resolution have served as the backbone of chiral separation. However, these methods can be time-consuming, costly, and inefficient, especially at large scales. As industries evolve and demand for enantiopure compounds increases, there is a growing need for innovative and efficient methods of chiral resolution. …

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Innovations in Membrane and Kinetic Resolution for Chiral Separation

Lead Chiral resolution techniques have long been a cornerstone in pharmaceutical and chemical industries, where separating enantiomers is crucial for producing safe and effective products. Among the most promising methods are membrane-based and kinetic resolution techniques, both of which have seen significant advancements in recent years. These methods are becoming increasingly relevant as industries seek more efficient, sustainable, and cost-effective approaches to chiral separation. 1. Overview of Membrane and Kinetic Techniques Membrane and kinetic resolution …

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Breaking Down the Methods: Chromatography and Crystallization in Chiral Resolution

Lead Chiral resolution, the process of separating enantiomers, is crucial in various fields such as pharmaceuticals, agrochemicals, and food industries. Chirality, as discussed in previous sections, involves molecules that are mirror images of each other but cannot be superimposed. This seemingly subtle difference leads to enantiomers having different biological, chemical, and pharmacological properties. The importance of chiral resolution has increased, especially in pharmaceutical industries, where the efficacy and safety of drugs can vary dramatically between …

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The Fundamentals of Chiral Resolution: Why Chirality Matters

Lead Chirality, a term derived from the Greek word “cheir,” meaning hand, is a fundamental concept in chemistry and biology that refers to the geometric property of an object not being superimposable on its mirror image. Much like our hands, chiral molecules exist in pairs known as enantiomers, which are mirror images of each other but cannot be aligned perfectly. Despite having the same molecular composition, these enantiomers can behave differently in biological systems due …

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Chiral Bioequivalence – An Explainer  

Introduction Chirality, or “handedness,” is the unique property of molecules that exist as non-superimposable mirror images, known as enantiomers. Drugs that exhibit handedness are referred to as chiral drugs. Chiral medications consisting of an equal (1:1) mixture of enantiomers are called Racemic drugs. In drug development, chirality is incredibly important because most biological molecules, like enzymes and receptors, are chiral. This characteristic affects how a drug interacts with biological targets, leading to significant differences in …

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Chiral Switch: Unlocking the Potential of Single Enantiomers

Synopsis Welcome to an exploration of Chiral Switch!!! Chiral switching revolutionizes the pharmaceutical landscape by transforming racemic drugs into their more effective single-enantiomer forms, enhancing therapeutic efficacy and reducing side effects This blog post delves into the intriguing realm of chiral switches, presenting key concepts such as chiral switch strategies, their advantages, and the regulatory environment focusing on bridging studies. An engaging mind map highlights notable case studies, both successful and unsuccessful, and also examines …

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Chiral Drugs: A twisted tale in pharmaceuticals

Synopsis Chiral drugs, those fascinating chemical compounds existing as mirror-image pairs or enantiomers, exhibit distinct biological properties. This post provides a comprehensive overview of chiral drugs, presenting key concepts through a visually engaging mind maps. It covers chirality’s historical roots and stereochemical nomenclature, delves into the specialized discipline of chiral pharmacology, and presents drug toxicity case studies. Additionally, it explores unichiral drugs, the importance of chiral purity, and the tools used for measuring it. Designed …

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The Future of Asymmetric Synthesis: Trends and Innovations”

Introduction Asymmetric synthesis has made significant strides in recent decades, becoming a crucial component of pharmaceutical, agrochemical, and fine chemical industries. The development of chiral catalysts and the understanding of stereoselective reactions have enabled the production of enantiomerically pure compounds on an industrial scale. This blog explores the future perspectives in chiral asymmetric synthesis, focusing on emerging technologies, interdisciplinary approaches, global impact, and the challenges that lie ahead. Emerging Technologies Green Chemistry Approaches The future …

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Asymmetric Synthesis in Industry: From Lab to Market

Introduction Asymmetric synthesis is a cornerstone of industrial chemistry, enabling the production of enantiomerically pure compounds that are essential in various sectors. Its importance lies in the ability to produce specific enantiomers that exhibit desired biological activities or material properties. Asymmetric synthesis is the process of turning a non-chiral starting material into a chiral product. This blog explores the industrial applications of chiral asymmetric synthesis, highlighting its critical role in pharmaceuticals, agrochemicals, fine chemicals, and …

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