{"id":2026,"date":"2022-09-05T10:28:41","date_gmt":"2022-09-05T04:58:41","guid":{"rendered":"https:\/\/chiralpedia.com\/blog\/?p=2026"},"modified":"2024-07-05T10:49:22","modified_gmt":"2024-07-05T05:19:22","slug":"l-dopa","status":"publish","type":"post","link":"https:\/\/chiralpedia.com\/blog\/l-dopa\/","title":{"rendered":"L-Dopa"},"content":{"rendered":"\n

<\/p>\n\n\n\n

Levodopa, L-Dopa, belong to a class of medications called dopamine agonists.  L-Dopa<\/a> is used to increase dopamine concentrations in the treatment of  Parkinson’s disease<\/a>. Most commonly, clinicians use levodopa as a dopamine replacement agent for the treatment of Parkinson disease. L-dopa is the precursor to dopamine and crosses the blood-brain barrier to increase dopamine neurotransmission.<\/p>\n\n\n\n

Chirality and Biological activity<\/strong><\/p>\n\n\n\n

L-dopa, the (S<\/em>)-enantiomer, is a chiral drug with one stereogenic center. It exists as a pair of enantiomers. The initial use of racemic dopa for the treatment of Parkinson’s disease resulted in a number of adverse effects viz. nausea, vomiting, anorexia, involuntary movements and granulocytopenia<\/a>. The use of L-dopa resulted in reducing the required dose, and adverse effects. The pharmacological activity resides in the (S)-enantiomer where as the (R<\/em>)-version harbors adverse effects.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Hence, L-dopa is marketed as a unichiral drug <\/a>due to serious side-effect, granulocytopenia, attributable to the D-isomer. <\/p>\n\n\n\n

Category<\/strong><\/p>\n\n\n\n

Dopamine agonist, Antiparkinson drug<\/p>\n\n\n\n

Nomenclature<\/strong><\/p>\n\n\n\n

3,4-dihydroxy-L-phenylalanine<\/p>\n\n\n\n

Exercise<\/strong><\/p>\n\n\n\n

Understand the nomenclature and stereo-descriptors employed<\/p>\n\n\n\n

References<\/strong><\/p>\n\n\n\n

Chiral drugs. Wikipedia, Wikipedia Foundation, 05\/09\/2022.  https:\/\/en.wikipedia.org\/wiki\/Chiral_drugs<\/a> and references therein<\/p>\n\n\n\n

Hassan Y. Aboul-Enein, Irving W. Wainer, The Impact of Stereochemistry on Drug Development and Use, John Wiley & Sons, New York, 1997. ISBN: 978-0-471-59644-8<\/p>\n\n\n\n

https:\/\/www.researchgate.net\/publication\/230209353_Toxicology_of_Chiral_Drugs<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Levodopa, L-Dopa, belong to a class of medications called dopamine agonists.  L-Dopa is used to increase dopamine concentrations in the treatment of  Parkinson’s disease. Most commonly, clinicians use levodopa as a dopamine replacement agent for the treatment of Parkinson disease. L-dopa is the precursor to dopamine and crosses the blood-brain barrier to increase dopamine neurotransmission. Chirality and Biological activity L-dopa, the (S)-enantiomer, is a chiral drug with one stereogenic center. It exists as a pair of enantiomers. The initial use …<\/p>\n

L-Dopa<\/span> Read More »<\/a><\/p>\n","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"","site-content-layout":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"categories":[43],"tags":[23,22,67,65],"ppma_author":[93],"class_list":["post-2026","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chirality","tag-chiral_drugs","tag-chirality","tag-chiralpedia","tag-cmotw"],"authors":[{"term_id":93,"user_id":1,"is_guest":0,"slug":"chiralusrblg","display_name":"Valliappan Kannappan","avatar_url":{"url":"https:\/\/chiralpedia.com\/blog\/wp-content\/uploads\/2024\/09\/vk.jpg","url2x":"https:\/\/chiralpedia.com\/blog\/wp-content\/uploads\/2024\/09\/vk.jpg"},"first_name":"","last_name":"","user_url":"https:\/\/chiralpedia.com\/blog\/","job_title":"Founder, chiralpedia.com","description":""}],"_links":{"self":[{"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/posts\/2026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/comments?post=2026"}],"version-history":[{"count":13,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/posts\/2026\/revisions"}],"predecessor-version":[{"id":2053,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/posts\/2026\/revisions\/2053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/media\/2043"}],"wp:attachment":[{"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/media?parent=2026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/categories?post=2026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/tags?post=2026"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/chiralpedia.com\/blog\/wp-json\/wp\/v2\/ppma_author?post=2026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}